Welcome
Recent advances in DNA sequencing technology are dramatically changing the scale
and scope of modern molecular biology. Next generation sequencing instruments
can sequence the equivalent of the human genome in a few days and at low cost,
compared to the years of effort and billions of dollars spent to sequence the
first human genome. This dramatic increase in efficiency has spurred tremendous
growth in applications for DNA sequencing. For example, whereas the human
genome project sought to sequence the genome of a small group of individuals,
the 1000 genomes projects aims to catalog the genomes of more than 1000
individuals from all over the globe.
Our research focuses on the development of scalable algorithms and systems to
analyze DNA sequences, concentrating on the assembly and alignment of next
generation sequencing reads, and related downstream analyses. These systems have
been used to reconstruct the genomes of previously unsequenced organisms, probe
sequence variations, and to explore a host of biological features across the
tree of life. Moving forward, one of the main challenges facing computational
biologists is the creation of analysis systems whose efficiency can match the
dramatic improvements in sequencing throughput. As such, we are particularly
interested in capitalizing on the latest advances in distributed and parallel
computing to advance the state of the art in bioinformatics and genomics.
Recent News
Upcoming Events
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Biology of Genomes
CSHL, Cold Spring Harbor, NY. May 8-12, 2012 |
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CSHL Symposium on Quantitative Biology: The Biology of Plants
CSHL, Cold Spring Harbor, NY. May 30 - June 4, 2012 |
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Beyond the Genome
Harvard Medical School, Boston MA. Sept 27 - Sept 29, 2012 |
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Personal Genomes & Medical Genomics
CSHL, Cold Spring Harbor NY. Nov 14 - Nov 17, 2012 |
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Michael Schatz
Cold Spring Harbor Laboratory
One Bungtown Road
Koch Building 1119
Cold Spring Harbor, NY 11724
Tel: (516) 367-5218
Cel: (703) 966-1987
Fax: (516) 367-8380
E-mail: mschatz <at> cshl.edu
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