Applying to the Schatzlab

The Schatzlab is a highly interactive research group known for outstanding research in computational biology. We are developing the computational models and systems needed for understanding the causes of diseases, for developing better foods and biofuels, and for unlocking the secrets of the processes of life. This work depends on having a team of highly motivated postdocs, graduate students, and bioinformatics engineers to explore all the different facets of these challenges. We will work together to establish and execute a premier research program in computational biology through the entire research life cycle: selecting research topics, establishing milestones, developing software and methods, analyzing data, writing papers & presenting your work. As you mature in the lab, you will be expected to take on more independence & responsibility so that you will be well prepared for your entire career path.

Computational Post-Doctoral Researchers

Applications are invited for a 2-3 year computational postdoctoral research position in the Schatz laboratory of Quantitative Biology at Cold Spring Harbor Laboratory. The researcher will develop novel methods for large-scale DNA and RNA sequence analysis related to human and/or plant genetics, such as developing methods for discovering de novo mutations related to autism, or for assembling and analyzing large complex plant genomes.

Ideal applicants will have:
  • A Ph.D. degree in Computer Science, Applied Mathematics, or related fields with a dissertation related to Computational Biology.
  • Strong programming and analytical skills, including experience with next-generation sequencing data.
  • Published at least two first author papers in English and demonstrated written communication skills in English.

To apply, please email me a letter of interest and current CV at mschatz @

Graduate Students

Graduate students interested in computational biology are encouraged to apply to the Watson School of Biological Sciences at Cold Spring Harbor Laboratory. This innovative 4-year program is especially designed for highly focused students with a strong research background looking for total immersion into research during their PhD program. The curriculum is extremely focused with just a single semester of fulltime coursework, followed by an applied laboratory rotation program, and in-depth thesis research.

In addition, the Schatzlab includes several students from neighboring Stony Brook University, in the Computer Science, Molecular and Cellular Biology, and Genetics programs. Stony Brook University is a flagship science and engineering campus of the State University of New York system, overing extensive courses and research opportunities across the physical sciences.

All graduate students must have strong programming and analytical skills, along with excellent communication abilities. New students will be expected to complete a semester long rotation during which they will complete a publishable project. Stony Brook students are encouraged to enroll in the Introduction to Computational Biology course, during which you can learn the fundamental of computational biology, and begin your rotation project.

Undergraduate Students

Undergraduate students are encouraged to apply to the NSF-sponsored Undergraduate Research Program, a 10 week paid summer research experience in Bioinformatics, Genetics & Genomics, Cellular and Molecular Biology, Plant Biology, Neuroscience, and Cancer Biology. Approximately 25 students a year are selected from around the world to work side-by-side with CSHL Investigators and gain hands-on experience. In the past few years, my students have developed novel computational and mathematical methods for analyzing, plant, animal, and human genomes, several of which have lead to significant publications.


The Schatzlab is housed in the Koch Building on the hillside campus of Cold Spring Harbor Laboratory, just minutes from downtown Huntington, and 30 miles east of Manhattan on the north shore of Long Island. The Koch Building is home to CSHL's new Center for Quantitative Biology, where an interdisciplinary team of mathematicians, physicists, statisticians, and computer scientists develop analytical approaches to interpret and understand large and complex data sets generated from experimental models as well as patient studies. In addition to collaborating with other members of the Quantitative Biology Center, Schatzlab members collaborate extensively with the other researchers on campus, and at nearby universities and hospitals.

Schatzlab members have access to considerable computational resources, including the 2000-core CSHL shared cluster "BlueHelix", >1PB of shared storage, high-memory servers with 512GB of RAM, a dedicated 96-core Hadoop cluster, and high-end GPUs for software development and data analysis. The computational development works side-by-side with the experimentalist on campus to probe deeply into a variety of biological systems and diseases. As such, lab members also have direct access to the CSHL Genome Sequencing Center, which currently has more than 20 high-throughput sequencers, including 9 Illumina HiSeq 2000 instruments, 2 PacBio RS instruments, and several others including GA2x, MiSeq, and by Ion Torrent.

CSHL Hillside Campus

Map to CSHL

Campus Map